New Search

Upper Mississippi River Cruise (St. Paul to St. Louis)
Prices From: £4,472
Balcony | £4,925 |
Call our Cruise Specialists
Saint Paul, Minnesota
Red Wing, Minnesota

La Crosse
The city of La Crosse is located in the southwest corner of Minnesota and is known for being a beautiful and welcoming place. The city is home to a variety of businesses and cultural attractions, making it a great place to visit.
Some of the businesses that call La Crosse home include the Mayo Clinic, Gundersen Lutheran Health System, and the University of Wisconsin-La Crosse. The city also boasts a variety of retail and dining options, as well as a number of parks and recreational facilities.
The cultural attractions in La Crosse include the La Crosse Symphony Orchestra, the Great River Shakespeare Festival, and the Pump House Regional Arts Center. The city is also home to a number of museums, including the Children's Museum of La Crosse and the Hixon House Museum.
Whether you're looking for a place to shop, dine, or simply enjoy the outdoors, La Crosse is sure to have something for you. So come and experience all that this great city has to offer!

Dubuque
If you find yourself in the Midwest, consider spending a day or two in Dubuque, Iowa. This charming city offers a variety of activities and attractions for visitors of all ages.
Start your Dubuque adventure at the National Mississippi River Museum & Aquarium. Here, you can learn all about the mighty Mississippi River and the creatures that call it home. After getting your fill of fish and river history, take a stroll across the Julien Dubuque Bridge for some incredible views.
Next, head downtown to explore the city’s shops and restaurants. Be sure to check out the art gallery at the Riverboat Lounge and the eclectic shops on Washington Street. If you’re looking for some fresh air, take a walk or bike ride along the scenic Waterfront Trail.
End your day with a sunset cruise on the Spirit of Dubuque. This double-decker paddlewheeler offers stunning views of the city skyline and is the perfect way to relax after a busy day of exploring.
Davenport, Iowa
Kingston, New York
Fort Madison, Iowa

St Louis
Fur trader Pierre Laclede established St Louis as a French trading post in 1764, settling at the confluence of the Mississippi and Missouri Rivers. It proved an ideal location, subsequently becoming a major port as well as a main departure point for explorers travelling the westbound wagon trails.
St Louis became a manufacturing centre for everything a pioneer would need on his journeys, such as saddles and guns, and it was here that explorers Lewis and Clark stocked up with provisions for their now famous expedition.
Today, St Louis is a modern, commercial, industrial, and cultural centre. It operates as the biggest city in Missouri and one of the largest inland ports in the country. Reminders of St Louis's frontier history are evident most visibly in the shining steel Gateway, the famous landmark dedicated to the pioneers of the Western Frontier.
The city has numerous personalities, existing as a mix of authentic America with a vaguely European air. Music from the nation's past floats from famous jazz and blues clubs, while paddle steamers dock along a riverfront filled with antique shops and restaurants now part of the revitalised Laclede's Landing Historic District.
We are proud to announce American Serenade won Cruise Critic’s 2023 Editors’ Picks Award for Best New River Cruise Ship of the Year, the first time an American ship has received this prestigious award.
We are proud to announce American Serenade won Cruise Critic’s 2023 Editors’ Picks Award for Best New River Cruise Ship of the Year, the first time an American ship has received this prestigious award.
According to Cruise Critic, “With extra-large staterooms and suites, trendy interior décor, an innovative hydraulic bow and retractable ramp, and one of the most gorgeous sun decks we’ve seen on a river-going ship, American Serenade sets the bar for domestic U.S. river cruising high.”
Like her sister ship American Symphony, the 180-passenger American Serenade introduces an updated modern interior design, integrating an elegant and refined aesthetic with our tradition for the spacious comfort found aboard all of our ships. Drawing inspiration from the geography across America, the new interior design highlights natural textural elements and serene color palettes.
American Serenade also showcases panoramic views throughout, including an impressive four-story glass atrium in the center of the ship. Ranging from 250 to 650 square feet, all of the spacious staterooms offer full-size bathrooms, roomy closets, and private balconies. The new ship also features an onboard fitness center and many spacious lounges where you can relax after the day’s adventures.
Unique Feature
Our series of modern American Riverboats has introduced the sophistication of a fine hotel to America's rivers. Accommodating just 180 guests, each ship ensures a personalised experience on board with our dedicated crew and onshore led by our expert guides. This revolutionary fleet features the largest-in-class staterooms, including single occupancy options, with full-size bathrooms, private balconies, and large opening picture windows. These riverboats also boast a spectacular four-story glass atrium, indoor and outdoor dining venues, a large fitness centre, multiple spacious lounges, and an incredible top deck showcasing a Skywalk with breathtaking river views.
Our modern American riverboats carry not only passengers, but also a rich history and a deep connection to the heart and soul of America.
Our team of Master Chefs takes great pride in offering you a customised American-inspired menu, featuring the finest cuisine, tailored with a delightful regional twist. Each menu offers something for everyone and changes to complement the season and the region in which guests are traveling. Our chefs are encouraged to use locally grown, sustainable ingredients to masterfully create the regionally inspired and exquisite cuisine we are known for. Fresh foods are brought aboard daily, some from the farms and vineyards that we visit along the way.
Restaurant
Indulge in the finest cuisine at our glass-enclosed restaurant, where you can enjoy the panoramic views of the spectacular scenery that defines every American Cruise Lines journey. Each menu showcases American specialties crafted from locally sourced ingredients, ensuring a fresh and flavourful dining experience. With ample seating available, all guests can enjoy their meals together in comfort and style.
Back Porch Café
This casual outdoor café is perfect for those seeking a lighter fare. From sandwiches and burgers to salads and more, there's something to satisfy every palate as you dine al fresco amidst the beauty of the surrounding landscapes.
Gratuities
American Cruise Lines is All-Inclusive and the per person fare includes passage, dining service, snacks, complimentary cocktail parties, entertainment on board the ship, onboard gratuities, as well as port charges and fees. Fares do not include all shore excursions (unless otherwise noted).
Onshore Excursions
100% American. Every port of call is in the U.S., every crewmember is American, and the story we tell along the way is about America. Each day is an opportunity to explore a new destination close to home.
American Cruise Lines has over 400 shore excursions which are meticulously planned and supported by personal guides who are well-versed in each region. There are typically two to four options at each port which cater to a variety of different interests and bring out the distinct flavour and unique culture of the destinations visited.
Unforgettable Small Group Adventures with Local Guides and Dedicated Support
Guided, small group excursions range from museums, historic landmarks, and culturally enriching sites to more active excursions such as hiking, kayaking, and bicycling. Every excursion is led by our local guide and accompanied by an American Cruise Lines’ team member who is always available to assist.
With various onshore options, guests can tailor their cruise experiences according to their passions and interests.
Pre-Cruise Packages
Extend the journey with more days to discover and explore. American Cruise Lines has a variety of Pre-Cruise Packages allowing our guests to fully immerse themselves in the region in which they are traveling and to seamlessly board the ship. These convenient packages include a 1 to 2-night stay in a premium hotel, breakfast, a city exploration which concludes at the ship, and concierge luggage service.
Onboard Experts & Historians
American Cruise Lines carefully selects industry experts to join us on each of our cruises. Their informal presentations, open discussions, and activities bring local history, nature and culture to life through their knowledge and passion for American heritage. These specialists, naturalists, and historians also attend shore excursions to give our guests behind the scenes insight into some of America’s most treasured destinations.
Onboard Music & Entertainment
Let American Cruise Lines guide you through the origins and rich traditions of music on America’s legendary rivers and waterways. These shores are home to many celebrated styles of music including Country, Jazz, Blues, and Rock 'n’ Roll. On board and ashore, enjoy music inspired by each unique region and learn its impact on the development of music in America.
Sky Lounge
Located at the aft of the ship, this elegantly designed lounge provides the perfect ambiance for socialising and admiring the scenery while enjoying a refreshing cocktail. The sizeable skylight overhead and large windows surrounding the room brings the outdoors in.
Sun Deck
Take a deep breath of fresh air and immerse yourself in the breathtaking 360-degree view of the passing scenery from this ideal setting. Savour the gentle breeze and scenic views while reclining on a comfortable lounge chair. Unwind with your favourite book, socialise with fellow travellers, play shuffleboard, or simply bask in the serenity of your surroundings.
The Game Room
This mid-ship lounge offers a peaceful enclave for reading a favourite book, having a quiet conversation, or simply reflecting on your adventures and those still to come. The cozy ambiance and thoughtfully designed furnishings invite guests to unwind, enveloped in a sense of calm amidst the excitement of the voyage.
The Study
For those seeking a quiet respite, this mid-ship study offers an ideal space to immerse yourself in a good book, engage in a friendly card game, or tackle a challenging puzzle. Sink into a plush armchair, surrounded by elegant decor that sets the stage for relaxation and rejuvenation.
River Lounge
This lounge at the bow is a bustling hub of activity during the day, perfect for casual conversations and mingling with fellow passengers. In the evening, it is transformed into a lively entertainment venue, promising memorable nights filled with laughter and camaraderie.
Storyteller Lounge
Tucked away in the heart of the ship, this mid-ship lounge offers a tranquil sanctuary for guests seeking moments of solitude or peaceful interaction. Away from the hustle and bustle, indulge in unhurried conversations or fully immerse yourself in a captivating book.
Sky Walk
For those seeking a bit of exercise while cruising, the Sky Walk on the sun deck is an ideal location for scenic strides. Offering a unique perspective high above the water, this walking track allows you to fully appreciate the beauty of the landscapes that unfold before you.
Fitness Centres
Our on-board Fitness Centre boasts a wide assortment of state-of-the-art exercise equipment, catering to every fitness enthusiast's needs. From treadmills and elliptical machines to free weights and resistance training equipment, guests can continue their workout regimen while enjoying rolling river views.
Balcony
Deluxe Balcony (DLXBLC)
Each 315 sq. ft. Deluxe Balcony stateroom offers large floor-to-ceiling glass doors which lead to a comfortable balcony with a table and chairs. Each room has a king-size bed but can be configured with two twin beds. Deluxe Balcony rooms have a full bathroom equipped with large shower, toiletries, hairdryer, and plush towels. Storage space in each room includes a wardrobe, full-size dresser, under-bed storage, and desk drawers. Each room also has individual climate control, TV, safe, USB charging ports, and complimentary WiFi.
Located on the 2nd Deck.
Standard Balcony (AAR)
SOLD OUT
Each 275 sq. ft. Standard Balcony stateroom offers large floor-to-ceiling glass doors which lead to a comfortable balcony with a table and chairs. Each room has a king-size bed but can be configured with two twin beds. Standard Balcony rooms have a full bathroom equipped with large shower, toiletries, hairdryer, and plush towels. Storage space in each room includes a wardrobe, full-size dresser, under-bed storage, and desk drawers. Each room also has individual climate control, TV, safe, USB charging ports, and complimentary WiFi.
Located on the Main Deck.
Premium Balcony (AAM)
SOLD OUT
Each 350 sq. ft. Premium Balcony stateroom offers large floor-to-ceiling glass doors which lead to a comfortable balcony with a table and chairs. Each room has a king-size bed but can be configured with two twin beds. Premium Balcony rooms have a full bathroom equipped with large shower, toiletries, hairdryer, and plush towels. Storage space in each room includes a wardrobe, full-size dresser, under-bed storage, and desk drawers. Each room also has individual climate control, TV, safe, USB charging ports, and complimentary WiFi.
Located on the 3rd Deck.
Single Balcony (SGLBAL)
SOLD OUT
Our dedicated single staterooms are 250 sq. ft. of space. Each room includes a floor-to-ceiling glass door leading to a full-size private balcony with a table and chairs. Single Balcony staterooms have a full-size bed, and a full bathroom equipped with large shower, toiletries, hairdryer, and plush towels. Storage space in each room includes a wardrobe, full-size dresser, under-bed storage, and desk drawers. Each room also has individual climate control, TV, safe, USB charging ports, and complimentary WiFi.
Located on the 2nd, 3rd, and 4th Deck.
Dubuque
If you find yourself in the Midwest, consider spending a day or two in Dubuque, Iowa. This charming city offers a variety of activities and attractions for visitors of all ages.
Start your Dubuque adventure at the National Mississippi River Museum & Aquarium. Here, you can learn all about the mighty Mississippi River and the creatures that call it home. After getting your fill of fish and river history, take a stroll across the Julien Dubuque Bridge for some incredible views.
Next, head downtown to explore the city’s shops and restaurants. Be sure to check out the art gallery at the Riverboat Lounge and the eclectic shops on Washington Street. If you’re looking for some fresh air, take a walk or bike ride along the scenic Waterfront Trail.
End your day with a sunset cruise on the Spirit of Dubuque. This double-decker paddlewheeler offers stunning views of the city skyline and is the perfect way to relax after a busy day of exploring.
La Crosse
The city of La Crosse is located in the southwest corner of Minnesota and is known for being a beautiful and welcoming place. The city is home to a variety of businesses and cultural attractions, making it a great place to visit.
Some of the businesses that call La Crosse home include the Mayo Clinic, Gundersen Lutheran Health System, and the University of Wisconsin-La Crosse. The city also boasts a variety of retail and dining options, as well as a number of parks and recreational facilities.
The cultural attractions in La Crosse include the La Crosse Symphony Orchestra, the Great River Shakespeare Festival, and the Pump House Regional Arts Center. The city is also home to a number of museums, including the Children's Museum of La Crosse and the Hixon House Museum.
Whether you're looking for a place to shop, dine, or simply enjoy the outdoors, La Crosse is sure to have something for you. So come and experience all that this great city has to offer!
St Louis
Fur trader Pierre Laclede established St Louis as a French trading post in 1764, settling at the confluence of the Mississippi and Missouri Rivers. It proved an ideal location, subsequently becoming a major port as well as a main departure point for explorers travelling the westbound wagon trails.
St Louis became a manufacturing centre for everything a pioneer would need on his journeys, such as saddles and guns, and it was here that explorers Lewis and Clark stocked up with provisions for their now famous expedition.
Today, St Louis is a modern, commercial, industrial, and cultural centre. It operates as the biggest city in Missouri and one of the largest inland ports in the country. Reminders of St Louis's frontier history are evident most visibly in the shining steel Gateway, the famous landmark dedicated to the pioneers of the Western Frontier.
The city has numerous personalities, existing as a mix of authentic America with a vaguely European air. Music from the nation's past floats from famous jazz and blues clubs, while paddle steamers dock along a riverfront filled with antique shops and restaurants now part of the revitalised Laclede's Landing Historic District.
Why Book With Us?





